Product Name :
p53 Rabbit pAb
Cat.No.:
db9894
Synonyms :
bbl; bfy; bhy; p44; p53; Tp53
Application :
WB, ICC/IF, FC, IP
Reactivity :
Mouse
Host species :
Rabbit
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Background
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
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Immunogen
Recombinant protein of mouse p53
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Gene ID
22059
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Swiss Prot
P02340
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Synonyms
bbl; bfy; bhy; p44; p53; Tp53
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Reactivity
Mouse
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Application
WB, ICC/IF, FC, IP
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Recommended dilution
WB: 1:1000
ICC/IF: 1:20
FC: 1:20
IP: 1:20
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Calculated MW
44 kDa
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Observed MW
53 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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