PML Protein Rabbit pAb - diagbio | 戴格生物

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PML Protein Rabbit pAb

db9346

Product Name : PML Protein Rabbit pAb

Cat.No.: db9346

Synonyms : MYL; RNF71; PP8675; TRIM19

Application : WB, IHC, ICC/IF, FC, IP

Reactivity : Human

Host species : Rabbit

Background The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human PML Protein
Gene ID 5371
Swiss Prot P29590
Synonyms MYL; RNF71; PP8675; TRIM19
Reactivity Human
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
IHC: 1:500
ICC/IF: 1:100
FC: 1:20
IP: 1:20
Calculated MW 98 kDa
Observed MW 98-117 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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