Chk2 Rabbit pAb - diagbio | 戴格生物

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Chk2 Rabbit pAb

db928

Datasheet

Product Name : Chk2 Rabbit pAb

Cat.No.: db928

Synonyms : CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425

Application : WB, IHC, ICC/IF, FC, IP

Reactivity : Human

Host species : Rabbit

Background In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Immunogen Recombinant protein of human Chk2
Gene ID 11200
Swiss Prot O96017
Synonyms CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425
Reactivity Human
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
IHC: 1:200
ICC/IF: 1:50
FC: 1:20
IP: 1:20
Calculated MW 61 kDa
Observed MW 61 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Autophagy Inhibition Potentiates the Anticancer Effects of a Bendamustine Derivative NL-101 in Acute T Lymphocytic Leukemia

发表于 BioMed research international - 2020年

Pubmed ID： 32149078

样本种属： Human

应用： WB
Downregulation of MGMT promotes proliferation of intrahepatic cholangiocarcinoma by regulating p21

发表于 Clinical & translational oncology : official publication of the Federation of Spanish Oncology - 2019年

Pubmed ID： 31264147

样本种属： Human

应用： WB

订购信息

Package Price (RMB)
20μL 598
50μL 998
100μL 1798
货期：现货