APAF1 Rabbit pAb - diagbio | 戴格生物

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APAF1 Rabbit pAb

db8521

Product Name : APAF1 Rabbit pAb

Cat.No.: db8521

Synonyms : CED4; APAF-1

Application : WB, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Immunogen Recombinant protein of human APAF1
Gene ID 317
Swiss Prot O14727
Synonyms CED4; APAF-1
Reactivity Human, Mouse, Rat
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:20
Calculated MW 142 kDa
Observed MW 142 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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