Product Name :
STAT3 Rabbit pAb
Cat.No.:
db7769
Synonyms :
APRF; HIES; ADMIO; ADMIO1
Application :
WB, IHC, ICC/IF, FC
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
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Immunogen
A synthetic peptide of human STAT3
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Gene ID
6774
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Swiss Prot
P40763
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Synonyms
APRF; HIES; ADMIO; ADMIO1
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC, ICC/IF, FC
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Recommended dilution
WB: 1:1000-1:5000
IHC: 1:100
ICC/IF: 1:100
FC: 1:200
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Calculated MW
88 kDa
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Observed MW
88 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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