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CD4 (7H9) Mouse mAb
db6525
Datasheet
- Background Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule/peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Immunogen Synthetic peptide conjugated to KLH
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Gene ID
920
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Swiss Prot
P01730
- Synonyms CD4; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; CD antigen CD4
- Reactivity Human, Rat, Mouse
- Application IHC-P
- Recommended dilution IHC: 1:50-1:100
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 7H9-1H6-7C6
- Isotype IgG1
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.
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Immunohistochemistry analysis of paraffin-embedded Human stomach tissue using CD4 (7H9) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Negative control was used by secondary antibody only. -
Immunohistochemical analysis of paraffin-embedded Human tonsils using CD4 (7H9) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Negative control was used by secondary antibody only. -
Immunohistochemistry analysis of paraffin-embedded mouse brain tissue using CD4 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Negative control was used by secondary antibody only. -
Immunofluorescence analysis of CD4 (7H9) in mouse colon tissue using CD4 (7H9) antibody(11A1)(red),and DAPI (blue). -
Immunofluorescence analysis of CD4 (7H9) in rat lung using CD4 antibody(11A1)(red),and DAPI (blue). -
Immunohistochemistry analysis of paraffin-embedded Human Amygdala using CD4 (7H9) antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
