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TNF alpha (6H2) Mouse mAb
db6521
Datasheet
- Background Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed/23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed/22517918).
- Immunogen Synthetic Peptide of TNF α
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Gene ID
7124
-
Swiss Prot
P01375
- Synonyms TNF; TNFA; TNFSF2; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a
- Reactivity Human, Rat, Mouse
- Application WB, IHC-P
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Recommended dilution
WB: 1:500-1:1000
IHC: 1:50-1:100 - Calculated MW 26 kDa
- Observed MW 17,25 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 6H2-4C6-5B6
- Isotype IgG1
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.
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Western blot analysis of TNF alpha in Recombinant Human TNF a Protein using TNF α antibody. -
Immunohistochemistry analysis of paraffin-embedded Human Tonsil Tissue using TNF aantibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
