您当前的位置：
Survivin (8B9) Mouse mAb
db6518
Datasheet
- Background Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed/9859993, PubMed/21364656, PubMed/20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed/16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed/20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed/20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed/18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed/9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed/20826784). May play a role in neoplasia (PubMed/10626797). Inhibitor of CASP3 and CASP7 (PubMed/21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed/12773388, PubMed/16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed/10626797).
- Immunogen Recombinant Protein of Survivin
-
Gene ID
332
-
Swiss Prot
O15392
- Synonyms BIRC5; API4; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor 4; Apoptosis inhibitor survivin
- Reactivity Human, Rat
- Application WB, IHC-P
-
Recommended dilution
WB: 1:500-1000
IHC: 1:50-1:100 - Calculated MW 16 kDa
- Observed MW 16 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 8B9-6G6-1G4
- Isotype IgG1
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.
-
Western blot analysis of Survivin in TF1, HL6 lysates using Survivin (8B9) antibody. -
Immunohistochemistry analysis of paraffin-embedded Human colon caricnoma using Survivin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
