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PYK2 (4B4) Mouse mAb
db6398
Datasheet
- Background PYK2/ PTK2B protein tyrosine kinase 2 beta, also known as PTK2B, PKB, PTK, CAKB, FAK2, FRNK. Entrez Protein NP_004094. It is a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
- Immunogen Purified recombinant fragment of PYK2 (aa815-997) expressed in E. Coli
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Gene ID
2185
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Swiss Prot
Q14289
- Synonyms PKB; PTK; CAKB; FAK2; FRNK; PTK2B
- Reactivity Human
- Application WB, IHC-P
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Recommended dilution
WB: 1:500-1:1000
IHC: 1:50-1:100 - Calculated MW 116 kDa
- Observed MW 116 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 4B4-D0-F3
- Isotype IgG2a
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.
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Western blot analysis of Pyk2 in A549, Ramos, Jurkat, THP-1 and Raji lysates using Pyk2 antibody. -
Immunohistochemistry analysis of paraffin-embedded Human Tonsil tissues using PYK2 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
