Lamin A/C (5D12) Mouse mAb - diagbio | 戴格生物

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Lamin A/C (5D12) Mouse mAb

db6351

Product Name : Lamin A/C (5D12) Mouse mAb

Cat.No.: db6351

Synonyms : LMNA; LMN1; Prelamin-A/C

Application : WB, ICC/IF

Reactivity : Human, Mouse, Rat

Host species : Mouse

Background Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the innernuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact withchromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role innuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal developmentof peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required forosteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping tomaintain the volume and strength of skeletal muscle and bone Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and prematuresenescence.
Immunogen Purified recombinant human LMNA protein fragments expressed in E.coli
Gene ID 4000
Swiss Prot P02545
Synonyms LMNA; LMN1; Prelamin-A/C
Reactivity Human, Mouse, Rat
Application WB, ICC/IF
Recommended dilution WB: 1:500-1:1000
ICC/IF: 1:50-1:200
Calculated MW 74 kDa
Observed MW 63,74 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 5D12-C6-E9
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Western blot analysis of Lamin A/C in MCF-7, A549 and Hela lysates using Lamin A/C antibody.
Immunofluorescence analysis of Lamin A/C (5D12) in A549 using Lamin A/C antibody.

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