AIF (8H1) Mouse mAb - diagbio | 戴格生物

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AIF (8H1) Mouse mAb

db6267

Product Name : AIF (8H1) Mouse mAb

Cat.No.: db6267

Synonyms : AIFM1; AIF; CMT2D; CMTX4; COWCK; NADMR; NAMSD; PDCD8; COXPD6

Application : WB, ICC/IF

Reactivity : Human

Host species : Mouse

Background Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Immunogen Purified recombinant human AIF protein fragments expressed in E.coli
Gene ID 9131
Swiss Prot O95831
Synonyms AIFM1; AIF; CMT2D; CMTX4; COWCK; NADMR; NAMSD; PDCD8; COXPD6
Reactivity Human
Application WB, ICC/IF
Recommended dilution WB: 1:500-1:1000
ICC/IF: 1:50-1:200
Calculated MW 67 kDa
Observed MW 67 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 8H1-B10-A12
Isotype IgG2a
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Western blot analysis of AIF (8H1) in Hela, Ramos, HepG2, MCF-7 and Jurkat lysates using AIF antibody.
Immunocytochemistry analysis of AIF (8H1) in HeLa using AIF antibody.

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