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Lamin A/C Mouse mAb
db6230
Datasheet
- Background Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the innernuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact withchromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role innuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal developmentof peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required forosteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping tomaintain the volume and strength of skeletal muscle and bone Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and prematuresenescence.
- Immunogen Purified recombinant human LMNA protein fragments expressed in E.coli
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Gene ID
4000
-
Swiss Prot
P02545
- Synonyms FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
- Reactivity Human, Mouse, Rat
- Application WB
- Recommended dilution WB: 1:500-1:1000
- Calculated MW 74 kDa
- Observed MW 74 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 3D6-F4-B7
- Isotype IgG2a
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.
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Western blot analysis of Lamin A in K562, C6, 3T3 and Hela lysates using Lamin A antibody.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
