c-Fos (7D6) Mouse mAb - diagbio | 戴格生物

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c-Fos (7D6) Mouse mAb

db6207

Product Name : c-Fos (7D6) Mouse mAb

Cat.No.: db6207

Synonyms : p55;AP-1;C-FOS

Application : WB

Reactivity : Human, Rat, Monkey

Host species : Mouse

Background Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor.In the heterodimer,FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites.On TGF-beta activation,forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling.Has a critical function in regulating the development of cells destined to form and maintain the skeleton.It is thought to have an important role in signal transduction,cell proliferation and differentiation.In growing cells,activates phospholipid synthesis,possibly by activating CDS1 and PI4K2A.This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Immunogen Purified recombinant human FOS protein fragments expressed in E.coli
Gene ID 2353
Swiss Prot P01100
Synonyms p55;AP-1;C-FOS
Reactivity Human, Rat, Monkey
Application WB
Recommended dilution WB: 1:500-1:1000
Calculated MW 41 kDa
Observed MW 62 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 7D6-A9-D4
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Western blot analysis of c-Fos in HCT116, COS7 and C6 lysates using c-Fos antibody.
Western blot analysis of c-Fos (7D6) in Hela(TSA treated ) and Hela lysates using c-Fos antibody.

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