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CD31 (2D3) Mouse mAb
db6192
Datasheet
- Background Induces susceptibility to atherosclerosis By similarity.Cell adhesion molecule which is required for leukocyte transendothelial migration(TEM)under most inflammatory conditions.Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment(LBRC)and is also essential for the LBRC membrane to be targeted around migrating leukocytes.Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals,and changes function on apoptosis,promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte.During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore.The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment).Isoform Delta15 is unable to protect against apoptosis.Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells(HUVEC).
- Immunogen Purified recombinant human CD31 protein fragments expressed in E.coli
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Gene ID
5175
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Swiss Prot
P16284
- Synonyms Cd31;Pecam;C85791;PECAM-1
- Reactivity Human
- Application WB, IP
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Recommended dilution
WB: 1:500-1:1000
IP: 1:20 - Calculated MW 83 kDa
- Observed MW 130 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 2D3-B4-C8
- Isotype IgG1
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.
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Western blot analysis of CD31 in THP-1 lysates using CD31 antibody. -
Immunoprecipitation analysis of CD31 (2D3) in THP-1 lysates using CD31 antibody.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
