Smad2 (6H5) Mouse mAb - diagbio | 戴格生物

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Smad2 (6H5) Mouse mAb

db6171

Product Name : Smad2 (6H5) Mouse mAb

Cat.No.: db6171

Synonyms : JV18;MADH2;MADR2;JV18-1;hMAD-2;hSMAD2

Application : WB, ICC/IF

Reactivity : Human, Mouse

Host species : Mouse

Background Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Immunogen Purified recombinant human Smad2 protein fragments expressed in E.coli
Gene ID 4087
Swiss Prot Q15796
Synonyms JV18;MADH2;MADR2;JV18-1;hMAD-2;hSMAD2
Reactivity Human, Mouse
Application WB, ICC/IF
Recommended dilution WB: 1:500-1:1000
ICC/IF: 1:50-1:200
Calculated MW 52 kDa
Observed MW 60 kDa
Host species Mouse
Clonality Monoclonal
Clonality No. 6H5-E3-C11
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in PBS, 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. Stable for 12 months from date of receipt.

Western blot analysis of Smad2 in Hela, A431, Jurkat and K562 lysates using Smad2 antibody.
Immunocytochemistry analysis of Smad2 (6H5) in HeLa using Smad2 antibody.
Western blot analysis of Smad2 (6H5) in 3T3 lysates using Smad2 antibody.

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