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Cyclin D2 (6E11) Mouse mAb
db6075
Datasheet
- Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and Ticular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).
- Immunogen Purified recombinant human Cyclin D2 protein fragments expressed in E.coli
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Gene ID
894
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Swiss Prot
P30279
- Synonyms KIAK0002
- Reactivity Human
- Application WB
- Recommended dilution WB: 1:500-1:1000
- Calculated MW 33 kDa
- Observed MW 38 kDa
- Host species Mouse
- Clonality Monoclonal
- Clonality No. 6E11-G6-F5
- Isotype IgG2b
- Purity Affinity Purification
- Conjugation Un-conjugated
- Storage/Stability Store at -20°C. Supplied in PBS, 50% Glycerol(pH 7.3), 0.02% sodium azide and 0.5% BSA . Stable for 12 months from date of receipt.
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Western blot analysis of Cyclin D2 in CHO-K1 lysates and CHO-K1 transfected by Cyclin D2fragment EGFP fusion proteinlysates using Cyclin D2 antibody.
订购信息
- Package Price (RMB)
- 50μL 1398
- 100μL 2398
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
