ULK1 Rabbit pAb - diagbio | 戴格生物

产品中心 Products Center

您当前的位置：

ULK1 Rabbit pAb

db5686

Product Name : ULK1 Rabbit pAb

Cat.No.: db5686

Synonyms : ATG1; ATG1A; UNC51; hATG1; Unc51.1

Application : WB

Reactivity : Human

Host species : Rabbit

Background Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).
Immunogen A synthetic peptide of human ULK1
Gene ID 8408
Swiss Prot O75385
Synonyms ATG1; ATG1A; UNC51; hATG1; Unc51.1
Reactivity Human
Application WB
Recommended dilution WB: 1:2000-1:10000
Calculated MW 113 kDa
Observed MW 130 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

订购信息