产品中心 Products Center
  1. 首页
  2. 产品中心
  3. 科研抗体
  4. 多克隆抗体
Phospho-PTEN (Ser380) Rabbit pAb
db4130
Datasheet

Product Name : Phospho-PTEN (Ser380) Rabbit pAb

Cat.No.: db4130

Synonyms : BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta

Application : WB, ICC/IF

Reactivity : Human, Mouse, Rat

Host species : Rabbit

  • Background This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
  • Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser380 of human PTEN
  • Gene ID 5728
  • Swiss Prot P60484
  • Synonyms BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta
  • Reactivity Human, Mouse, Rat
  • Application WB, ICC/IF
  • Recommended dilution WB: 1:1000
    ICC/IF: 1:20-1:100
  • Calculated MW 47 kDa
  • Observed MW 54 kDa
  • Host species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
  • Package Price (RMB)
  • 20μL 698
  • 50μL 1398
  • 100μL 2398
  • 货期：现货
相关产品
For research use only. Not intended for diagnostic.