HSD17B1 Rabbit pAb - diagbio | 戴格生物

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HSD17B1 Rabbit pAb

db4038

Datasheet

Product Name : HSD17B1 Rabbit pAb

Cat.No.: db4038

Synonyms : E2DH; HSD17; EDHB17; EDH17B2; SDR28C1; 17-beta-HSD; 20-alpha-HSD

Application : WB, IHC, ICC/IF, FC, IP

Reactivity : Human

Host species : Rabbit

Background This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Immunogen A synthetic peptide of human HSD17B1
Gene ID 3292
Swiss Prot P14061
Synonyms E2DH; HSD17; EDHB17; EDH17B2; SDR28C1; 17-beta-HSD; 20-alpha-HSD
Reactivity Human
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:2000-1:10000
IHC: 1:20-1:100
ICC/IF: 1:20-1:100
FC: 1:50
IP: 1:20
Calculated MW 35 kDa
Observed MW 35 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Downregulation of Organic Anion Transporter 4

发表于 Drug metabolism and disposition: the biological fate of chemicals - 2022年

Pubmed ID： 5074787

订购信息

Package Price (RMB)
20μL 598
50μL 998
100μL 1798
货期：现货