Presenilin 2 Rabbit pAb - diagbio | 戴格生物

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Presenilin 2 Rabbit pAb

db380

Product Name : Presenilin 2 Rabbit pAb

Cat.No.: db380

Synonyms : AD4; PS2; AD3L; STM2; CMD1V

Application : WB, IHC, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human Presenilin 2
Gene ID 5664
Swiss Prot P49810
Synonyms AD4; PS2; AD3L; STM2; CMD1V
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, IP
Recommended dilution WB: 1:2000
IHC: 1:20
ICC/IF: 1:20-1:50
IP: 1:20
Calculated MW 50 kDa
Observed MW 23 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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