Phospho-AKT1 (Ser473) Rabbit pAb
Product Name :
Phospho-AKT1 (Ser473) Rabbit pAb
Cat.No.:
db3626
Synonyms :
AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
Application :
WB, IHC
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding Ser473 of human AKT1
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Gene ID
207
11651
24185
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Swiss Prot
P31749
P31750
P47196
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Synonyms
AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC
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Recommended dilution
WB: 1:2000
IHC: 1:50
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Calculated MW
56 kDa
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Observed MW
56 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
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