CDKN2A/p16INK4a Rabbit pAb - diagbio | 戴格生物

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CDKN2A/p16INK4a Rabbit pAb

db3540

Product Name : CDKN2A/p16INK4a Rabbit pAb

Cat.No.: db3540

Synonyms : ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A

Application : WB, ICC/IF, FC

Reactivity : Human

Host species : Rabbit

Background This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Immunogen Recombinant protein of human CDKN2A/p16INK4a
Gene ID 1029
Swiss Prot P42771
Synonyms ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A
Reactivity Human
Application WB, ICC/IF, FC
Recommended dilution WB: 1:1000
ICC/IF: 1:20-1:100
FC: 1:20
Calculated MW 17 kDa
Observed MW 17 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Downregulation of MGMT promotes proliferation of intrahepatic cholangiocarcinoma by regulating p21

发表于 Clinical & translational oncology : official publication of the Federation of Spanish Oncology - 2019年

Pubmed ID： 31264147

样本种属： Human

应用： WB

订购信息

Package Price (RMB)
20μL 598
50μL 998
100μL 1798
货期：现货