CD31 Rabbit pAb - diagbio | 戴格生物

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CD31 Rabbit pAb

db3309

Product Name : CD31 Rabbit pAb

Cat.No.: db3309

Synonyms : Cd31; Pecam; C85791; PECAM-1

Application : WB, ICC/IF

Reactivity : Mouse, Rat

Host species : Rabbit

Background Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore.
Immunogen Recombinant protein of mouse CD31
Gene ID 18613
Swiss Prot Q08481
Synonyms Cd31; Pecam; C85791; PECAM-1
Reactivity Mouse, Rat
Application WB, ICC/IF
Recommended dilution WB: 1:1000
ICC/IF: 1:20
Calculated MW 83 kDa
Observed MW 130 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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