Phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221) Rabbit pAb
Product Name :
Phospho-JNK1/JNK2/JNK3 (Thr183/Thr183/Thr221) Rabbit pAb
Cat.No.:
db3253
Synonyms :
JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
Application :
WB, IHC, ICC/IF, FC, IP
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
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Immunogen
A synthetic phosphopeptide corresponding to residues surrounding
Thr183 of human JNK1
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Gene ID
5599
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Swiss Prot
P45983
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Synonyms
JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC, ICC/IF, FC, IP
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Recommended dilution
WB: 1:1000
IHC: 1:50
ICC/IF: 1:20
FC: 1:20
IP: 1:20
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Calculated MW
48 kDa
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Observed MW
46,54 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
698
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50μL
1398
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100μL
2398
- 货期：现货
For research use only. Not intended for diagnostic.
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