Caspase-1 Rabbit pAb - diagbio | 戴格生物

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Caspase-1 Rabbit pAb

db3022

Product Name : Caspase-1 Rabbit pAb

Cat.No.: db3022

Synonyms : ICE; P45; IL1BC

Application : WB, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
Immunogen Recombinant protein of human Caspase-1
Gene ID 834
12362
25166
Swiss Prot P29466
P29452
P43527
Synonyms ICE; P45; IL1BC
Reactivity Human, Mouse, Rat
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:50
Calculated MW 45 kDa
Observed MW 48,10 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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