AFP Recombinant Rabbit mAb - diagbio | 戴格生物

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AFP Recombinant Rabbit mAb

db30200

Datasheet

Product Name : AFP Recombinant Rabbit mAb

Cat.No.: db30200

Synonyms : AFPD; FETA; HPAFP

Application : IHC

Reactivity : Human

Host species : Rabbit

Background Alpha-fetoprotein (AFP) is a 65 kDa glycoprotein found in the mammalian fetal liver, yolk sac, and GI tract. While AFP expression in adult cells is low, it is aberrantly expressed in adult liver cancer cells. The tumor suppressor gene p53 and β?catenin are both involved in the regulation of AFP expression. In normal adult cells, p53 binds to the repressor region of the AFP gene, thereby blocking transcription. Mutations in both p53 and β-catenin are associated with aberrant expression of AFP. Research studies have shown that elevated serum AFP levels are predictive of hepatocellular carcinoma.
Immunogen Synthetic peptide. This information is proprietary to Biolynx
Swiss Prot P02771
Synonyms AFPD; FETA; HPAFP
Reactivity Human
Application IHC
Recommended dilution IHC: 1:100-1:200
Calculated MW 67 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. BP6244
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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