Product Name :
PYK2 Rabbit pAb
Cat.No.:
db295
Synonyms :
PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK
Application :
WB, IHC, ICC/IF
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic peptide of human PYK2
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Gene ID
2185
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Swiss Prot
Q14289
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Synonyms
PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC, ICC/IF
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Recommended dilution
WB: 1:1000-1:2000
IHC: 1:50-1:200
ICC/IF: 1:20
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Calculated MW
116 kDa
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Observed MW
116 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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