产品中心 Products Center
  1. 首页
  2. 产品中心
  3. 科研抗体
  4. 多克隆抗体
Glutathione Peroxidase 4 Rabbit pAb
db2697
Datasheet

Product Name : Glutathione Peroxidase 4 Rabbit pAb

Cat.No.: db2697

Synonyms : GPx-4; PHGPx; snGPx; GSHPx-4; mtPHGPx

Application : WB, IHC, ICC/IF, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

  • Background The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes 10 and 17. [provided by RefSeq, Aug 2017]
  • Immunogen A synthetic peptide of mouse Glutathione Peroxidase 4
  • Gene ID 625249
  • Swiss Prot O70325
  • Synonyms GPx-4; PHGPx; snGPx; GSHPx-4; mtPHGPx
  • Reactivity Human, Mouse, Rat
  • Application WB, IHC, ICC/IF, FC
  • Recommended dilution WB: 1:2000
    IHC: 1:50
    ICC/IF: 1:50
    FC: 1:50
  • Calculated MW 22 kDa
  • Observed MW 22 kDa
  • Host species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purity Affinity Purification
  • Conjugation Un-conjugated
  • Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
  • Package Price (RMB)
  • 20μL 598
  • 50μL 998
  • 100μL 1798
  • 货期：现货
相关产品
For research use only. Not intended for diagnostic.