Phospho-ERK1/2 (Thr202/Thr185) Rabbit pAb - diagbio | 戴格生物

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Phospho-ERK1/2 (Thr202/Thr185) Rabbit pAb

db269

Datasheet

Product Name : Phospho-ERK1/2 (Thr202/Thr185) Rabbit pAb

Cat.No.: db269

Synonyms : ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK

Application : WB, IHC, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr185 of human ERK2
Gene ID 5594
Swiss Prot P28482
Synonyms ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, IP
Recommended dilution WB: 1:1000
IHC: 1:20
ICC/IF: 1:20
IP: 1:20
Calculated MW 41 kDa
Observed MW 44,42 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Estradiol reduced 5-HT reuptake by downregulating the gene expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor β and the MAPK/ERK signaling pathway

发表于 European journal of pharmacology - 2022年

Pubmed ID： 35398393

样本种属： Rat

应用： WB
Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway

发表于 Human molecular genetics - 2021年

Pubmed ID： 33791790

样本种属： Mouse

应用： WB

订购信息

Package Price (RMB)
20μL 698
50μL 1398
100μL 2398
货期：现货