Phospho-RAF1 (Ser43) Rabbit pAb - diagbio | 戴格生物

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Phospho-RAF1 (Ser43) Rabbit pAb

db24819

Product Name : Phospho-RAF1 (Ser43) Rabbit pAb

Cat.No.: db24819

Synonyms : NS5; CRAF; Raf-1; c-Raf; CMD1NN

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser43 of human RAF1
Gene ID 5894
110157
24703
Swiss Prot P04049
Q99N57
P11345
Synonyms NS5; CRAF; Raf-1; c-Raf; CMD1NN
Reactivity Human, Mouse, Rat
Application WB
Recommended dilution WB: 1:1000
Calculated MW 73 kDa
Observed MW 73 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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