Product Name :
BRCA2 Rabbit pAb
Cat.No.:
db23708
Synonyms :
FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2
Application :
WB
Reactivity :
Human
Host species :
Rabbit
-
Background
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020]
-
Immunogen
A synthetic peptide of human BRCA2
-
Gene ID
675
-
Swiss Prot
P51587
-
Synonyms
FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2
-
Reactivity
Human
-
Application
WB
-
Recommended dilution
WB: 1:1000
-
Calculated MW
384 kDa
-
Observed MW
384 kDa
-
Host species
Rabbit
-
Clonality
Polyclonal
-
Isotype
IgG
-
Purity
Affinity Purification
-
Conjugation
Un-conjugated
-
Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
-
Package
Price (RMB)
-
20μL
598
-
50μL
998
-
100μL
1798
- 货期:现货
For research use only. Not intended for diagnostic.