MLKL Rat mAb - diagbio | 戴格生物

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MLKL Rat mAb

db22650

Product Name : MLKL Rat mAb

Cat.No.: db22650

Synonyms : hMLKL

Application : WB

Reactivity : Human, Mouse, Rat

Host species : Rat

Background This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Immunogen A synthetic peptide of human MLKL
Gene ID 197259
Swiss Prot Q9D2Y4
Synonyms hMLKL
Reactivity Human, Mouse, Rat
Application WB
Recommended dilution WB: 1:1000
Calculated MW 54 kDa
Observed MW 54 kDa
Host species Rat
Clonality Monoclonal
Isotype IgG1
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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