Product Name :
PTEN Rabbit pAb
Cat.No.:
db21985
Synonyms :
BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta
Application :
WB, IHC, FC, IP
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
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Immunogen
A synthetic peptide of human PTEN
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Gene ID
5728
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Swiss Prot
P60484
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Synonyms
BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC, FC, IP
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Recommended dilution
WB: 1:1000
IHC: 1:200
FC: 1:50
IP: 1:20
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Calculated MW
47 kDa
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Observed MW
54 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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