Product Name :
MCM4 Rabbit pAb
Cat.No.:
db21805
Synonyms :
NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21
Application :
WB, FC, IP
Reactivity :
Human, Mouse
Host species :
Rabbit
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Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic peptide of human MCM4
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Gene ID
4173
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Swiss Prot
P33991
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Synonyms
NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21
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Reactivity
Human, Mouse
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Application
WB, FC, IP
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Recommended dilution
WB: 1:2000-1:10000
FC: 1:20-1:100
IP: 1:20
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Calculated MW
97 kDa
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Observed MW
97 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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