Phospho-Amyloid Precursor Protein (Thr743) Rabbit pAb - diagbio

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Phospho-Amyloid Precursor Protein (Thr743) Rabbit pAb

db21719

Product Name : Phospho-Amyloid Precursor Protein (Thr743) Rabbit pAb

Cat.No.: db21719

Synonyms : AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma

Application : WB, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Thr743 of human Amyloid Precursor Protein
Gene ID 351
Swiss Prot P05067
Synonyms AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma
Reactivity Human, Mouse, Rat
Application WB, ICC/IF, IP
Recommended dilution WB: 1:1000
ICC/IF: 1:20
IP: 1:20
Calculated MW 87 kDa
Observed MW 100 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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