Collagen I Rabbit pAb - diagbio | 戴格生物

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Collagen I Rabbit pAb

db21697

Product Name : Collagen I Rabbit pAb

Cat.No.: db21697

Synonyms : OI1; OI2; OI3; OI4; EDSC; CAFYD; EDSARTH1

Application : WB, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Immunogen Recombinant protein of human Collagen I
Gene ID 1277
Swiss Prot P02452
Synonyms OI1; OI2; OI3; OI4; EDSC; CAFYD; EDSARTH1
Reactivity Human, Mouse, Rat
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:20
Calculated MW 139 kDa
Observed MW 139 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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