PEN2 Rabbit pAb - diagbio | 戴格生物

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PEN2 Rabbit pAb

db21233

Product Name : PEN2 Rabbit pAb

Cat.No.: db21233

Synonyms : PEN2; PEN-2; MDS033; ACNINV2; MSTP064

Application : WB, IHC, ICC/IF, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Immunogen A synthetic peptide of human PEN2
Gene ID 55851
Swiss Prot Q9NZ42
Synonyms PEN2; PEN-2; MDS033; ACNINV2; MSTP064
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC
Recommended dilution WB: 1:1000
IHC: 1:50
ICC/IF: 1:50
FC: 1:20-1:100
Calculated MW 12 kDa
Observed MW 12 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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