Product Name :
Doublecortin Rabbit pAb
Cat.No.:
db212
Synonyms :
DC; DBCN; LISX; SCLH; XLIS
Application :
WB, IHC, ICC/IF
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
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Immunogen
Recombinant protein of human Doublecortin
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Gene ID
1641
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Swiss Prot
O43602
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Synonyms
DC; DBCN; LISX; SCLH; XLIS
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC, ICC/IF
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Recommended dilution
WB: 1:1000
IHC: 1:20
ICC/IF: 1:50
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Calculated MW
41 kDa
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Observed MW
41 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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