Phospho-Crk p38 (Tyr221) Rabbit pAb - diagbio | 戴格生物

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Phospho-Crk p38 (Tyr221) Rabbit pAb

db20993

Product Name : Phospho-Crk p38 (Tyr221) Rabbit pAb

Cat.No.: db20993

Synonyms : p38; CRKII

Application : WB, ICC/IF

Reactivity : Human

Host species : Rabbit

Background This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr221 of human Crk p38
Gene ID 1398
Swiss Prot P46108
Synonyms p38; CRKII
Reactivity Human
Application WB, ICC/IF
Recommended dilution WB: 1:1000
ICC/IF: 1:20
Calculated MW 34 kDa
Observed MW 38 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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