LATS1/WARTS Rabbit pAb - diagbio | 戴格生物

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LATS1/WARTS Rabbit pAb

db20847

Product Name : LATS1/WARTS Rabbit pAb

Cat.No.: db20847

Synonyms : wts; WARTS

Application : WB, FC

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Immunogen Recombinant protein of human LATS1/WARTS
Gene ID 9113
Swiss Prot O95835
Synonyms wts; WARTS
Reactivity Human, Mouse, Rat
Application WB, FC
Recommended dilution WB: 1:1000
FC: 1:50
Calculated MW 127 kDa
Observed MW 140 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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