Hamartin Rabbit pAb - diagbio | 戴格生物

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Hamartin Rabbit pAb

db20716

Product Name : Hamartin Rabbit pAb

Cat.No.: db20716

Synonyms : LAM; TSC

Application : WB, IHC, FC

Reactivity : Human

Host species : Rabbit

Background This gene is a tumor suppressor gene that encodes the growth inhibitory protein hamartin. The encoded protein interacts with and stabilizes the GTPase activating protein tuberin. This hamartin-tuberin complex negatively regulates mammalian target of rapamycin complex 1 (mTORC1) signalling which is a major regulator of anabolic cell growth. This protein also functions as a co-chaperone for Hsp90 that inhibits its ATPase activity. This protein functions as a facilitator of Hsp90-mediated folding of kinase and non-kinase clients, including Tsc2 and thereby preventing their ubiquitination and proteasomal degradation. Mutations in this gene have been associated with tuberous sclerosis. [provided by RefSeq, Apr 2018]
Immunogen A synthetic peptide of human Hamartin
Gene ID 7248
Swiss Prot Q92574
Synonyms LAM; TSC
Reactivity Human
Application WB, IHC, FC
Recommended dilution WB: 1:5000
IHC: 1:20
FC: 1:200-1:1000
Calculated MW 130 kDa
Observed MW 150-170 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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