Phospho-Chk1 (Ser280) Rabbit pAb - diagbio | 戴格生物

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Phospho-Chk1 (Ser280) Rabbit pAb

db20551

Product Name : Phospho-Chk1 (Ser280) Rabbit pAb

Cat.No.: db20551

Synonyms : CHK1

Application : WB, IP

Reactivity : Human

Host species : Rabbit

Background The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Ser280 of human Chk1
Gene ID 1111
Swiss Prot O14757
Synonyms CHK1
Reactivity Human
Application WB, IP
Recommended dilution WB: 1:1000
IP: 1:20
Calculated MW 54 kDa
Observed MW 54 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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