Phospho-STAT6 (Tyr641) Rabbit pAb - diagbio | 戴格生物

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Phospho-STAT6 (Tyr641) Rabbit pAb

db20436

Product Name : Phospho-STAT6 (Tyr641) Rabbit pAb

Cat.No.: db20436

Synonyms : STAT6B; STAT6C; D12S1644; IL-4-STAT

Application : WB, FC, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr641 of human STAT6
Gene ID 6778
Swiss Prot P42226
Synonyms STAT6B; STAT6C; D12S1644; IL-4-STAT
Reactivity Human, Mouse, Rat
Application WB, FC, IP
Recommended dilution WB: 1:1000
FC: 1:50
IP: 1:20
Calculated MW 94 kDa
Observed MW 110 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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