Product Name :
Caspase-8 Rabbit pAb
Cat.No.:
db201
Synonyms :
CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Application :
WB, IHC
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
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Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
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Immunogen
A synthetic peptide of human Caspase-8
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Gene ID
841
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Swiss Prot
Q14790
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Synonyms
CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC
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Recommended dilution
WB: 1:1000
IHC: 1:200-1:500
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Calculated MW
55 kDa
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Observed MW
55 kDa
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Host species
Rabbit
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Clonality
Polyclonal
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Storage/Stability
Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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20μL
598
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50μL
998
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100μL
1798
- 货期：现货
For research use only. Not intended for diagnostic.
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