Epac1 Rabbit pAb - diagbio | 戴格生物

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Epac1 Rabbit pAb

db2006

Product Name : Epac1 Rabbit pAb

Cat.No.: db2006

Synonyms : EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI

Application : WB, IHC, ICC/IF, IP

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Immunogen A synthetic peptide of human Epac1
Gene ID 10411
Swiss Prot O95398
Synonyms EPAC; EPAC1; bcm910; HSU79275; CAMP-GEFI
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, IP
Recommended dilution WB: 1:2000
IHC: 1:20
ICC/IF: 1:20
IP: 1:20
Calculated MW 104 kDa
Observed MW 104 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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