Dnmt3b Recombinant Rabbit mAb - diagbio | 戴格生物

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Dnmt3b Recombinant Rabbit mAb

db15761

Product Name : Dnmt3b Recombinant Rabbit mAb

Cat.No.: db15761

Synonyms : ICF; ICF1; M.HsaIIIB

Application : WB, ICC/IF

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. [provided by RefSeq, May 2011]
Immunogen A synthetic peptide of human Dnmt3b
Gene ID 1789
Swiss Prot Q9UBC3
Synonyms ICF; ICF1; M.HsaIIIB
Reactivity Human, Mouse, Rat
Application WB, ICC/IF
Recommended dilution WB: 1:1000-1:2000
ICC/IF: 1:20-1:50
Calculated MW 96 kDa
Observed MW 96 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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