Caspase-8 Rabbit pAb - diagbio | 戴格生物

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Caspase-8 Rabbit pAb

db1571

Datasheet

Product Name : Caspase-8 Rabbit pAb

Cat.No.: db1571

Synonyms : CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8

Application : WB

Reactivity : Human

Host species : Rabbit

Background This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Immunogen A synthetic peptide of human Caspase-8
Gene ID 841
Swiss Prot Q14790
Synonyms CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
Reactivity Human
Application WB
Recommended dilution WB: 1:1000
Calculated MW 55 kDa
Observed MW 55 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

订购信息

Package Price (RMB)
20μL 598
50μL 998
100μL 1798
货期：现货