ULK1 Recombinant Rabbit mAb - diagbio | 戴格生物

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ULK1 Recombinant Rabbit mAb

db15467

Product Name : ULK1 Recombinant Rabbit mAb

Cat.No.: db15467

Synonyms : ATG1; ATG1A; UNC51; hATG1; Unc51.1

Application : WB, IHC, ICC/IF

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Background Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.
Immunogen A synthetic peptide of human ULK1
Gene ID 8408
Swiss Prot O75385
Synonyms ATG1; ATG1A; UNC51; hATG1; Unc51.1
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF
Recommended dilution WB: 1:2000
IHC: 1:100
ICC/IF: 1:20-1:100
Calculated MW 113 kDa
Observed MW 130 kDa
Host species Rabbit
Clonality Monoclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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