RIP (DGR16113) Rabbit mAb - diagbio | 戴格生物

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Recombinant DGRmAb^®

RIP (DGR16113) Rabbit mAb

db14919

Datasheet

Product Name : RIP (DGR16113) Rabbit mAb

Cat.No.: db14919

Synonyms : RIP; Rinp; Rip1; D330015H01Rik

Application : WB, ICC/IF, FC, IP

Reactivity : Mouse

Host species : Rabbit

Background Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.
Immunogen Recombinant protein of mouse RIP
Gene ID 19766
Swiss Prot Q60855
Synonyms RIP; Rinp; Rip1; D330015H01Rik
Reactivity Mouse
Application WB, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
ICC/IF: 1:100-1:200
FC: 1:200-1:500
IP: 1:20-1:50
Calculated MW 75 kDa
Observed MW 75 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR16113
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

Western blot analysis of extracts from RAW264.7，3T3 cells using db14919 at 1:1000.

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