BackgroundThe protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Storage/StabilityStore at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
Western blot detection of GSK3 beta in Jurkat,C6,CHO-K1,Hela cell lysates using GSK3 beta antibody(1:1000 diluted).
Western blot analysis of extracts from HeLa,MCF-7 cells using db14808 at 1:2000.
Immunohistochemical analysis of paraffin-embedded human Cholangiocarcinoma using db14808 antibody.